Alprazolam |
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The drug has anxiolytic, sedative, as well as anticonvulsant and anti-anxiety effects. The calming effect is achieved by a noticeable decrease in the state of fear, tension and anxiety. A person who has taken a dose of Xanax falls asleep faster and easier. Sleep, at the same time, becomes deeper and longer.
How it affects the body
Xanax belongs to the group of benzodiazepine tranquilizers. It is used in medicine in the treatment of neurotic disorders. According to its effect on the human body, it has some similarities with valium, but with a lesser hypnotic effect, and a more pronounced anti-anxiety effect.
Indications for appointment
As practice and clinical research data show, Alprazolam is most effective in pathologies accompanied by anxiety and fear. They include:
- panic, obsessive-compulsive, acute stress, generalized anxiety disorder;
- some forms of depression;
- phobias;
- alcohol or drug withdrawal (with caution due to the risk of complications);
- severe course of premenstrual syndrome;
- somatic diseases accompanied by anxiety syndrome.
Long-term use of this drug leads to an increase in tolerance. After 1.5-2 months, the patient begins to feel the symptoms of withdrawal syndrome in the intervals between taking the drug. During such a period, lasting from several weeks to months, the daily dosage of the drug is gradually reduced to complete withdrawal.
A number of studies have noted that a reduction in the dose of benzodiazepine tranquilizers may be accompanied by withdrawal syndrome and the return of clinical manifestations of the underlying disease, especially in cases of abrupt discontinuation of therapy.
Despite the widespread perception of the existing risk of drug dependence, data from numerous studies indicate that the frequency of dependence among patients taking alprazolam is relatively low. The authors note that dependence on benzodiazepines is a relatively rare phenomenon and occurs mainly in people who abuse alcohol or drugs.
Some other side effects of alprazolam should also be mentioned. A number of studies have revealed a deterioration in the processes of perception and reproduction of new information. This feature must be taken into account when driving a car. It is also important to note the interaction of alprazolam with alcohol, because many patients with anxiety symptoms independently resort to taking alcohol to alleviate the condition.
Method of administration and dosage
The method of application and dosage regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
Individual. It is recommended to take the minimum effective dose. The dose is corrected during treatment, depending on the achieved effect and tolerability. If it is necessary to increase the dose, it should be increased gradually, first in the evening and then in the afternoon.
Contraindications and application features
Based on the peculiarities of metabolism, Alprazolam is prescribed with caution in chronic pathologies of the liver and kidneys. In such cases, individual dose selection is required. It is impossible to exclude the gradual accumulation of the drug, a high risk of intoxication. Therefore, in such diseases, the drug is prescribed only for strict indications and the inability to find a safer analogue.
During the course of treatment with Alprazolam, drugs that reduce the activity of liver enzymes are contraindicated. These are such means:
- antiviraldrugs;
- antifungaldrugs;
- some antibacterial drugs (in particular, erythromycin and ciprofloxacin);
- antidepressants;
- anti-ulcer drugs (omeprazole), etc.
Due to the risk of overdose, narcotic analgesics, other sedatives and sleeping pills, alcohol are strictly prohibited. Alprazolam is contraindicated incase of:
- respiratory failure, obstructive chronic lung diseases;
- individual intolerance and allergic reaction;
- pregnancy due to the risk of severe congenital malformations of the fetus; it is also necessary to abandon breastfeeding;
- childhood and adolescence;
- severe depression with suicide attempts (benzodiazepines increase the symptoms of the disorder).